BPC-157 + TB-500 5mg each

This combination includes two peptides—BPC-157 and TB-500—each contributing to the stimulation of tissue repair and healing through different mechanisms.

• BPC-157: A synthetic peptide derived from a protective protein found in the stomach lining. It has been shown in preclinical studies to accelerate healing of muscles, tendons, and ligaments by promoting angiogenesis (the formation of new blood vessels) and regulating the production of growth factors.
• TB-500 (Thymosin Beta-4): A synthetic peptide that plays a key role in cell migration, tissue regeneration, and reducing inflammation. It is involved in the regulation of actin polymerization, a process essential for cell movement and tissue repair.

Together, these peptides work synergistically to enhance the body's natural healing processes.

Potential Synergy Between BPC-157 and TB-500 in Wound Repair

Research suggests that BPC-157 and TB-500, both of which promote wound healing through different biochemical pathways, may have synergistic effects when used together.

Cell Migration

Successful wound healing depends heavily on fibroblasts, which regulate the production of extracellular matrix, and on immune cells. For these cells to effectively repair tissue, they must migrate to the injury site—a process that relies on the protein actin. BPC-157 increases actin production at the gene level, while TB-500, an actin-binding protein, helps sequester actin where it is needed most for filament formation, enabling cell movement. Together, these peptides enhance both the amount and function of actin, accelerating the migration of fibroblasts and immune cells to wounds.

Growth Hormone Involvement

Both TB-500 and BPC-157 influence growth hormone activity during healing. BPC-157 upregulates growth hormone receptor expression on fibroblasts, extending their lifespan and enhancing their ability to regenerate soft tissue. TB-500 complements this effect by providing sufficient actin to support the prolonged survival and function of these cells.

Combining TB-500, BPC-157, collagen, and a growth hormone secretagogue may significantly improve wound healing rates, potentially establishing a new gold standard in treatment protocols.

Research Applications

The BPC-157 + TB-500 blend is primarily utilized in scientific studies focusing on:

• Tissue Repair: Investigating their potential to accelerate the healing of various types of wounds, including skin, muscle, and tendon injuries.
• Tissue Regeneration: Exploring their effects on the regeneration of damaged tissues by stimulating angiogenesis, collagen synthesis, and cell migration.
• Reduced Inflammation: Assessing their role in modulating the inflammatory response and reducing swelling and pain associated with injuries.
• Neuroprotective Effects: Studying the potential neuroprotective properties of BPC-157, which may support brain health and recovery from neurological injuries.
• Cardiovascular Support: Examining the angiogenic properties of both peptides, which may contribute to improved cardiovascular health by promoting the formation of new blood vessels and supporting circulation.

These applications are part of ongoing research aimed at understanding the broader implications of this peptide blend in various biological processes.

Product Specifications

• Form: Lyophilized (freeze-dried) powder for reconstitution.
• Purity: 99% or higher, ensuring high-quality material for research purposes.
• Packaging: Each package contains 1 vial, each with 10 milligrams of the peptide blend (5mg BPC-157, 5mg TB-500).

This product is intended strictly for laboratory research and is not approved for human consumption.

Resources

• C.-H. Chang, W.-C. Tsai, M.-S. Lin, Y.-H. Hsu, and J.-H. S. Pang, “The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration,” J. Appl. Physiol., vol. 110, no. 3, pp. 774-780, Oct. [Physiology.org] 
• J. Kim and Y. Jung, “Potential Role of Thymosin Beta 4 in Liver Fibrosis,” Int. J. Mol. Sci., vol. 16, no. 5, pp. 10624-10635, May 2015. [NCBI] 
• C.-H. Chang, W.-C. Tsai, Y.-H. Hsu, and J.-H. S. Pang, “Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts,” Mol. Basel Switz., vol. 19, no. 11, pp. 19066-19077, Nov. 2014. [NCBI] 
• Song, Ran; Choi, Hyun; Yang, Hyung-In; Yoo, Myung; Park, Yong-Beom; Kim, Kyoung. “Association between serum thymosin 4 levels of rheumatoid arthritis patients and disease activity and response to therapy,” Clinical Rheumatology, vol. 31, pp. 1253-1258, 2012. https://doi.org/10.1007/s10067-012-2011-7 [ResearchGate] 
• D. Philp et al., “Thymosin B4 Promotes Angiogenesis, Wound Healing, and Hair Follicle Development,” Mechanisms of Ageing and Development, vol. 125, no. 2, pp. 113-115, Feb. 2004, doi:10.1016/mad.2003.11.005. [PubMed]