Selank 5mg

Selank is a synthetic peptide derived froSelank is a synthetic heptapeptide analogue of the naturally occurring human peptide tuftsin. Developed in Russia, it has been utilized for its potential neuroprotective and cognitive-enhancing properties. Selank's structure is designed to be more stable and longer-lasting than its parent peptide, tuftsin.

Mechanism of Action

Selank's effects are believed to arise from its interaction with various neurotransmitter systems:

• GABAergic System: Selank may allosterically modulate GABA_A receptors, enhancing the inhibitory effects of GABA and contributing to its anxiolytic properties.
• Serotonergic System: It has been shown to influence serotonin metabolism, which is crucial for mood regulation and sleep-wake cycles.
• Dopaminergic System: Selank may affect dopamine receptors, which play a role in mood and cognitive functions.

Additionally, Selank has been found to elevate brain-derived neurotrophic factor (BDNF) levels in the hippocampus, supporting neuroplasticity and cognitive function.

Selank Research

Selank Anxiety Effects Based on Genes Related to GABA Neurotransmitter

Dr. Anastasiya Volkova of the Institute of Molecular Genetics in Russia reports that numerous clinical studies demonstrate Selank’s strong anti-anxiety and neuroprotective effects, comparable to classical anxiolytics like benzodiazepines, which modulate GABA_A receptors and enhance GABA’s inhibitory action. Selank reduces anxiety, improves mood, lowers stress, and positively influences memory and learning. Unlike benzodiazepines, it is not habit-forming and does not cause withdrawal symptoms or amnesia.

Animal studies reveal that Selank modulates the expression of 52 genes related to GABA signaling, including 7 genes heavily influenced and 45 showing some expression changes. This suggests Selank directly affects gene expression in neurons, likely altering the affinity of GABA receptors for GABA, which may explain its synergistic effect with benzodiazepines and other GABA agonists.

Selank and benzodiazepines show similar efficacy in reducing anxiety, particularly generalized anxiety disorder, but combined therapy may better treat unpredictable chronic mild stress.

Enkephalin Degradation and Anxiety

Selank may modulate anxiety partly through inhibition of enkephalin degradation. Anxiety and phobic disorders correlate with increased blood enkephalinase activity, reducing the half-life of natural enkephalins. By preventing their breakdown, Selank helps preserve endogenous anxiolytic peptides. Animal studies support this mechanism.

Selank and Immune System Effects in Anxiety

In depression patients, Selank suppresses IL-6 gene expression, an inflammatory cytokine, but this effect is absent in healthy individuals. This suggests Selank may be especially useful in anxiety-asthenic disorders, which involve anxiety with fatigue, pain, and other somatic symptoms. Unlike benzodiazepines, Selank can alleviate these asthenic symptoms, likely due to IL-6 modulation and protection of enkephalins.

Selank regulates 34 inflammation-related genes in rats, including chemokines, cytokines, and receptors. It notably alters expression of the Bel6 gene, critical in immune development. These findings reveal complex immunomodulatory effects of Selank.

Selank’s Impact on Memory and Learning

Anxiety negatively impacts memory and learning, but Selank not only reduces anxiety-related cognitive impairment but may directly enhance cognition. Rat studies show Selank stabilizes memory traces and improves memory storage independent of anxiety level.

Gene expression changes in the hippocampus after Selank administration include modulation of 36 genes, many encoding plasma membrane proteins involved in ion-dependent learning and memory processes. Selank may ease the formation and recall of memories.

It has also shown potential to restore cognitive function after brain injury in rats, possibly via inhibition of the catecholamine system, with implications for traumatic brain injury therapy.

Selank and Pain Modulation

Selank inhibits enzymes degrading natural enkephalins—opioid peptides that modulate pain and stress responses. By preserving enkephalins, Selank may blunt stress effects on cognition, learning, and concentration.

Pharmacology and Usage

Selank exhibits minimal side effects, with low oral and excellent subcutaneous bioavailability in mice. Dosages in mice do not scale directly to humans. Selank is sold strictly for educational and scientific research and is not intended for human consumption. Purchase only if licensed.

Research Applications

Selank is primarily utilized in scientific studies focusing on:

• Anxiolytic Effects: Investigating its potential to reduce anxiety without the sedative effects associated with traditional anxiolytics.
• Cognitive Enhancement: Exploring its role in improving memory, learning, and attention.SCIRP
• Neuroprotection: Assessing its ability to protect neurons from damage and support recovery from neurological injuries.
• Mood Regulation: Studying its effects on mood stabilization and potential antidepressant-like properties.

Product Specifications

• Form: Lyophilized (freeze-dried) powder for reconstitution.
• Purity: Typically ≥98%, ensuring high-quality material for research purposes.
• Packaging: Each vial contains 5 mg of Selank.
• Storage: Store lyophilized Selank at temperatures below -18°C. After reconstitution, store at 4°C and use within 2-7 days.m tuftsin with anxiolytic, cognitive-enhancing, and neuroprotective effects. It reduces anxiety, stress, and depression symptoms while improving mental performance. Perfect for those seeking natural emotional balance and cognitive support. Buy Selank now and calm your mind with confidence!

Referenced Citations:

1. Volkova, A. et al., “Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission,” Frontiers in Pharmacology, vol. 7, Feb. 2016. 
2. Kasian, A. et al., “Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats,” Behavioural Neurology, 2017. 
3. Zozulya, A.A. et al., “The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity,” Bulletin of Experimental Biology and Medicine, vol. 131, no. 4, Apr. 2001. 
4. Sokolov, Y. et al., “Effects of Selank on behavioral reactions and plasma enkephalin-degrading enzyme activities in mice,” Bulletin of Experimental Biology and Medicine. 
5. Uchakina, N. et al., “Immunomodulatory effects of Selank in patients with anxiety-asthenic disorders,” Zhurnal Nevrologii i Psikhiatrii im. S. S. Korsakova, vol. 108, no. 5, 2008. 
6. Zozulia, A.A. et al., “Efficacy and possible mechanisms of action of a new peptide anxiolytic Selank in generalized anxiety disorders and neurasthenia,” Zhurnal Nevrologii i Psikhiatrii im. S. S. Korsakova, vol. 108, no. 4, 2008. 
7. Kolomin, T. et al., “Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank,” Regulatory Peptides, vol. 170, no. 1-3, Oct. 2011.  
8. Agapova, T.I. et al., “Effect of Semax on brain-derived neurotrophic factor and nerve growth factor gene expression in rat hippocampus and frontal cortex,” Molecular Genetics, Microbiology, and Virology, 2008. 
9. Semenova, T.P. et al., “Experimental optimization of learning and memory processes by Selank,” Eksp. Klin. Farmakol., vol. 73, no. 8, 2010. 
10. Kolomin, T.A. et al., Zhurnal Vysshei Nervnoi Deyatelnosti, vol. 63, no. 3, 2013.
11. Semenova, T.P. et al., “Effect of Selank on cognitive processes after cerebral catecholamine system damage during early ontogeny,” Bulletin of Experimental Biology and Medicine, vol. 144. 
12. Kost, N.V. et al., “Semax and Selank inhibit enkephalin-degrading enzymes from human serum,” Bioorganic Chemistry, vol. 27, no. 3, Jun. 2001.